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<!doctype html>

<!-- 
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  This file is part of Vidjil <http://www.vidjil.org>, High-throughput Analysis of V(D)J Immune Repertoire
  Copyright (C) 2011-2017 by Bonsai bioinformatics
  at CRIStAL (UMR CNRS 9189, Université Lille) and Inria Lille
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  "Vidjil" is free software: you can redistribute it and/or modify
  it under the terms of the GNU General Public License as published by
  the Free Software Foundation, either version 3 of the License, or
  (at your option) any later version.

  "Vidjil" is distributed in the hope that it will be useful,
  but WITHOUT ANY WARRANTY; without even the implied warranty of
  MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
  GNU General Public License for more details.

  You should have received a copy of the GNU General Public License
  along with "Vidjil". If not, see <http://www.gnu.org/licenses/>
-->

<html>
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    <head>
        <meta charset="utf-8">
        <title>Vidjil</title>
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        <link rel="shortcut icon" href="./images/favicon-v.ico" type="image/x-icon">
        <link rel="icon" href="./images/favicon-v.ico" type="image/x-icon">
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        <link rel="stylesheet" type="text/css" href="css/fonts/ubuntu/stylesheet.css" /> 
        <link rel="stylesheet" type="text/css" href="css/fonts/ubuntu-mono/stylesheet.css" /> 
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        <link rel="stylesheet" type="text/css" href="css/icons/fontello/css/fontello.css" />
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        <link rel="stylesheet" type="text/css" href="css/icons/fontello/css/animation.css" />
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        <link rel="stylesheet" href="css/vmi/vmi.css" />
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        <link id="palette" rel="stylesheet" type="text/css" href="css/light.css" />
        <link id="seg_highlight" rel="stylesheet" type="text/css" href="css/segmenter_highlight.css" />
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        <link rel="stylesheet" href="css/jstree_themes/default/style.min.css" />
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        <script data-main="js/app.js" src="js/lib/require.js"></script>

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    </head>


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    <body>
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        <div id="file_menu" >
            <span class="closeButton" onclick="cancel();">X</span>

            <h2>Vidjil <span class='logo'>(beta)</span> &ndash; V(D)J repertoire browsing and analysis</h2>

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            Data file (.vidjil):<br/>
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            <input id="upload_json" type="file" name="json" /></br>
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            <p class='help'>The .vidjil file stores a set of clones on several points.</p>
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            Analysis file (.analysis, optional):<br/>
            <input id="upload_pref" type="file" name="pref" /></br>
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            <p class='help'>The .analysis file stores all parameters set by the user (tags, colors, manual clusters).</p>
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            <button id="start_import_json" onclick="document.getElementById('file_menu').style.display='none';
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            m.load('upload_json','upload_pref', 200)">start</button> 
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        </div>

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        <div id="axis_choice" >
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            <span class="closeButton" onclick="cancel();">X</span>
            <h2>analysis menu</h2>

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            Analysis file:<br/>
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            <input id="upload_analysis" type="file" name="analysis" /></br></br>

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            <button onclick="document.getElementById('axis_choice').style.display='none';
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                                    m.loadAnalysis('upload_analysis');">start</button> 
        </div>
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        <div id="upload_summary" style="" class="menu" onmouseover="showSelector('upload_summary_selector');" onmouseout="hideSelector();">
            <span id="upload_summary_label">upload</span>
            <div id="upload_summary_selector" class="selector"><div>

            </div></div>
        </div>

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        <div id="add_clone_menu">
            <span class="closeButton" onclick="cancel();">X</span>
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            <h2>Add clones from sequences</h2>
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            <textarea id="addclone_input" placeholder="Sequence(s) (Fasta)"></textarea>
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            <button onclick="document.getElementById('add_clone_menu').style.display = 'none';
                m.addManualClones('addclone_input');">Add</button>
        </div>

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        <!-- TOP-CONTAINER -->
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        <div id="top-container" onmouseout="hideSelector()">
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            <div id="menu-container">
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                <div class="menu devel-mode" onmouseover="showSelector('vmiSelector');">vmi
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                    <!-- Div is filld programmatically with vmi menu -->
                    <div class="selector" id="vmiSelector"></div>
                </div>
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                <div class="menu" id="top_info">
                    <!--Div is filled programmatically -->
                </div>
                <div class="menu" id="db_menu" onmouseover="showSelector('dbSelector');" style="display : none">patients
                    <div id="dbSelector" class="selector"><div>
                        <div class="menu_box">
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                            <a class="buttonSelector" onclick="javascript:db.call('sample_set/all', {'type': 'patient', 'page': 0})">open patient list</a>
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                        </div>
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                        <div class="menu_box">
                            <div id="last_loaded_file">
                            </div>
                        </div>
                    </div></div>
                </div>
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                <div class="menu" id="static_file_menu" onmouseover="showSelector('fileSelector');" style="display : none">file
                  <div id="fileSelector" class="selector"><div>
                        <div class="menu_box">
                            <div id="upload_list">
                            </div>
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                        </div>
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                  </div></div>
                </div>
 
                <div class="menu" id="demo_file_menu" onmouseover="showSelector('demoSelector');">import/export
                    <div id="demoSelector" class="selector"><div>
                        <div class="menu_box">
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                            <a id="import_data_anchor" class="buttonSelector" onclick="javascript:loadData()">import data (.vidjil)</a>
                            <a id="import_data_analysis" class="buttonSelector" onclick="javascript:loadAnalysis()">import analysis</a>
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                        </div>
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                        <div class="menu_box devel-mode">
                            <a class="buttonSelector" id ="add_clones" onclick="javascript:showAddManualCloneMenu()">add clones from sequences</a>
                        </div>
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                        <!--<a class="buttonSelector" onclick="javascript:m.resetAnalysis()">reset analysis</a> -->
                        <!--<a class="buttonSelector" onclick="javascript:reset()">reset all</a> -->
                        <div class="menu_box">
                          <a class="buttonSelector" id="export_sample_report" onclick="javascript:report.reportHTMLdiag()">export report (sample)</a>
                          <a class="buttonSelector" id="export_monitor_report" onclick="javascript:report.reportHTML()">export report (monitor)</a>
                        </div>
                        <div class="menu_box">
                            <a class="buttonSelector" id="export_analysis" onclick="javascript:m.saveAnalysis()">export analysis</a>
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                            <a class="buttonSelector" id="export_svg1" onclick="javascript:m.exportViewToPNG(document.querySelector('#visu2_svg'))">export top graph (PNG)</a>
                            <a class="buttonSelector" id="export_svg2" onclick="javascript:m.exportViewToPNG(document.querySelector('#visu_svg'))">export bottom graph (PNG)</a>
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                            <a class="buttonSelector" id="export_csv" onclick="javascript:m.exportCSV()">export csv (visible clones)</a>
                            <a class="buttonSelector" id="export_fasta" onclick="javascript:m.exportFasta()">export fasta (selected clones)</a>
                        </div>
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                        <div class="menu_box">
                            <a class="buttonSelector" id="export_fasta" onclick="javascript:segment.add_all_germline_to_segmenter()">add germline genes (experimental)</a>
                        </div>
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                    </div></div>
                </div>

                <div class="menu" id="cluster_menu" onmouseover="showSelector('clusterSelector');" > cluster
                    <div id="clusterSelector" class="selector"><div>
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                        <div class="menu_box">
                          <a class="buttonSelector" onclick="m.restoreClusters();">revert to previous clusters</a>
                        </div>
                        <div class="menu_box">
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                          <a class="buttonSelector" onclick="m.merge();">cluster selected clones</a>
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                          <a class="buttonSelector" onclick="m.clusterBy(function(id){return m.clone(id).getGene(5)});">cluster by V/5' </a>
                          <a class="buttonSelector" onclick="m.clusterBy(function(id){return m.clone(id).getGene(3)});">cluster by J/3' </a>
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                          <a class="buttonSelector" onclick="m.clusterBy(function(id){return m.clone(id).getSegAASequence('junction')});">cluster by CDR3 </a>
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                          <a class="buttonSelector" onclick="m.clusterBy(function(id){return m.clone(id).germline});">cluster by locus </a>
                          <a class="buttonSelector devel-mode" onclick="m.similarity_builder.DBscan(95,0.001);">cluster by DBscan (experimental) </a>
                          <a class="buttonSelector" onclick="m.similarity_builder.cluster_me(95,0.1);">cluster by similarity </a>
                          <div id="clusterby_button"> </div>
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                        </div>
                        <div class="menu_box">
                          <a class="buttonSelector" onclick="m.break();">break selected clusters</a>
                          <a class="buttonSelector" onclick="m.resetClusters();">break all clusters</a>
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                        </div>
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                    </div></div>
                </div>

                <div class="menu" id="color_menu" onmouseover="showSelector('colorSelector');" > color by
                    <div class="div-menu-selector"><select class="menu-selector" onchange="m.changeColorMethod(this.value)">
                        <option value="Tag">tag</option>
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                        <option value="clone">clone</option>
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                        <option value="cdr3">CDR3</option>
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                        <option value="V">V/5'</option>
                        <option value="J">J/3'</option>
                        <option value="N">N</option>
                        <option value="system" id="color_system_button">locus/germline</option>
                        <option value="abundance">abundance</option>
                        <option value="productive">productivity</option>
                    </select></div>
                </div>

                <div class="menu" id="filter_menu" onmouseenter="builder.build_displaySelector();" onmouseover="showSelector('filterSelector');" > filter
                    <div id="filterSelector" class="selector"><div>
                        <div class="menu_box">
                            <span id="top_label"></span></br>
                            <input id="top_slider" type="range" min="5" max="100" step="5" value="10" onchange="m.displayTop(this.value)" />
                        </div>
                    </div></div>
                </div>
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                <div class="menu" id="settings_menu" onmouseenter="builder.build_settings();" onmouseover=" showSelector('settingsSelector');" > settings
                    <div id="settingsSelector" class="selector"><div>
                        <div class="menu_box">
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                            normalization
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                            <form name="normalize_list_2" id="normalize_list_2">
                                <label id="no_normalization" for="no_normalization_input" class="buttonSelector" onclick="m.set_normalization(m.NORM_FALSE); m.update()">
                                    <input id="no_normalization_input" type="radio" name="normalization" value="no_norm" />
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                                    no normalization
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                                </label>
                                <label id="external_normalization"  for="external_normalization_input" class="buttonSelector" onclick="m.set_normalization(m.NORM_EXTERNAL); m.update()">
                                    <input id="external_normalization_input" type="radio" name="normalization" value="external_normalization" />
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                                    from input data
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                                </label>
                                <label id="expected_normalization"  for="expected_normalization_input" class="buttonSelector" onclick="m.set_normalization(m.NORM_EXPECTED); m.update()">
                                    <input id="expected_normalization_input" type="radio" name="normalization" value="expected_normalization" />
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                                    set on a given clone
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                                </label>
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                            </form>
                            <form name="normalize_list" id="normalize_list" class="devel-mode">
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                            </form>
                        </div>
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                        <div class="menu_box">
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                            size display</br>
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                            <label for="menuNotationScientific" class="buttonSelector" onclick="m.changeNotation('scientific', true)"><input id="menuNotationScientific" type="radio" name="notation" value="scientific" />scientific notation</label>
                            <label for="menuNotationPercent" class="buttonSelector" onclick="m.changeNotation('percent', true)"><input id="menuNotationPercent" type="radio" name="notation" value="percent" checked />percent</label>
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                        </div>
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                        <div class="menu_box">
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                            sample key</br>
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                            <label for="menuTimeFormName" class="buttonSelector" onclick="m.changeTimeFormat('name', true)"><input id="menuTimeFormName" type="radio" name="time" value="name" checked />name</label>
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                            <label for="menuTimeFormShort" class="buttonSelector" onclick="m.changeTimeFormat('short_name', true)"><input id="menuTimeFormShort" type="radio" name="time" value="short_name"/>name (short)</label>
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                            <label for="menuTimeFormSample" class="buttonSelector" onclick="m.changeTimeFormat('sampling_date', true)"><input id="menuTimeFormSample" type="radio" name="time" value="sampling_date" />sampling date</label>
                            <label for="menuTimeFormSamplePlus" class="buttonSelector" onclick="m.changeTimeFormat('delta_date', true)"><input id="menuTimeFormSamplePlus" type="radio" name="time" value="delta_date" />day after first sample</label>
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                        </div>
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                        <div class="menu_box">
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                             N regions in clone names</br>
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                             <label for="menuCloneNotNucNum" class="buttonSelector" onclick="m.changeCloneNotation('nucleotide_number', true)"><input id="menuCloneNotNucNum" type="radio" name="show_name" value="nucleotide_number" />length</label>
                             <label for="menuCloneNotSeqShort" class="buttonSelector" onclick="m.changeCloneNotation('short_sequence', true)"><input id="menuCloneNotSeqShort" type="radio" name="show_name" value="short_sequence" checked />sequence (when short)</label>
                             <label for="menuCloneNotSeq" class="buttonSelector" onclick="m.changeCloneNotation('full_sequence', true)"><input id="menuCloneNotSeq" type="radio" name="show_name" value="full_sequence" />sequence (always)</label>
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                        </div>
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                        <div class="menu_box">
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                             alleles in clone names</br>
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                             <label for="menu_allele_never" class="buttonSelector" onclick="m.changeAlleleNotation('never', true)"><input id="menu_allele_never" type="radio" name="menu_allele" value="never" />never</label>
                             <label for="menu_allele_when_not_01" class="buttonSelector" onclick="m.changeAlleleNotation('when_not_01', true)"><input id="menu_allele_when_not_01" type="radio" name="menu_allele" value="when_not_01" checked />when not *01</label>
                             <label for="menu_allele_always" class="buttonSelector" onclick="m.changeAlleleNotation('always', true)"><input id="menu_allele_always" type="radio" name="menu_allele" value="always" />always</label>
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                        </div>
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                        <div class="menu_box devel-mode">
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                            primer set</br>
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                            <label for="primerBiomed2" class="buttonSelector" onclick="m.switchPrimersSet('biomed2')"><input type="radio" id="primerBiomed2" name="primers" value="biomed2" />biomed2</label>
                            <label for="primer_fictif" class="buttonSelector" onclick="m.switchPrimersSet('primer_fictif')"><input type="radio" id="primer_fictif" name="primers" value="primer_fictif" />primer_fictif</label>
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			    <!-- TODO : construire liste à partir des data disponibles/chargées dans le model.
                            TODO : passer ça en liste deroulante ? -->
                        </div>
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                        <!--
                        <div class="submenu" id="system_menu" style="display:none">
                            <div class="menu_box">
                                selected locus/germline (for the grid)</br>
                                <ul id="germline_list">
                                </ul>
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                            </div>
                        </div>
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                        -->
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                        <!--menu graph/dbscan -->
                        <div class="submenu" style="display:none">

                            <div class="menu_box">
                                <div id="DBSCANEpsSlider">
                                <input id="changeEps" type="range" min="0" max="40" step="1" value="0" onchange="m.changeEps(this.value)" />
                                </div>
                            </div>


                            <div class="menu_box">
                                <div id="DBSCANNbrSlider">
                                <input id="changeNbr" type="range" min="0" max="100" step="1" value="0" onchange="m.changeNbr(this.value)" />
                                </div>
                            </div>


                            <div class="menu_box">
                                <div id="EditDistanceSlider">
                                </br>
                                <input id="displayMax_slider" type="range" min="1" max="20" step="1" value="10" onchange="sp.displayDistanceMax(this.value)" style="display:none"/>
                                </div>
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                            </div>
                        </div>
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                    </div></div>
                </div>
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                <div id="debug_menu" class="menu" onmouseover="showSelector('adminSelector');" style="display : none"> development
                    <div id="adminSelector" class="selector"><div>
                        <input type="checkbox" onclick=" this.checked ? $('#fps').css('display', '') : $('#fps').css('display', 'none');">display fps</input></br>
                        <input type="checkbox" onclick=" this.checked ? console.openLog() : console.closeLog() ;">log</input>
                        <div class="buttonSelector" onclick="m.changeTimeFormat('delta_date_no_zero', true)"><input type="radio" name="time" value="delta_date_no_zero">day after first sample (no zero)</input></div>
                    </div></div>
                </div>
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            </div>

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            <div class="menu" id="alert" style="float: right;"></div>
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            <div id="logo" style="float: right;" onclick="console.log({'type': 'popup', 'default':'welcome'})">Vidjil <span class='logo'>(beta)</span></div>
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            <div class="menu" style="float: right" onmouseover="showSelector('helpSelector');"> help
                <div id="helpSelector" class="selector"><div>
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                    <a class="buttonSelector getHelp" onclick="report.sendMail()">get support</a>
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                    <a class="buttonSelector" href="http://www.vidjil.org/doc/user" target="_blank">manual</a>
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                    <a class="buttonSelector" href="http://www.vidjil.org/doc/tutorial/mastering-vidjil.html" target="_blank">tutorial</a>
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                    <a class="buttonSelector devel-mode" onclick="my_tips.reset()">reset tips of the day</a>
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                </div></div>
                </div>
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            <div style="float: right" class="menu" onmouseover="showSelector('paletteSelector');"> palette 
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                <div id="paletteSelector" class="selector"><div>
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                    <a class="buttonSelector" onclick="changeStyle('solarizeL')">light</a>
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                    <a class="buttonSelector" onclick="changeStyle('display')">light (presentation)</a>
                    <a class="buttonSelector" onclick="changeStyle('solarizeD')">dark</a>
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                </div></div>
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            </div>
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            <div style="float: right; margin: 5px;" id='live-ajax'>
                <div class="active-container">
                    <img src="images/ajax-loader.gif" />
                </div>
            </div>
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            <div id="fps" style="float: right; display: none"> </div>
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            <div id="header_messages" class="message_container header"></div>
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<!--
	    <div class="menu" style="float: right; margin-right:100px"><span style="padding: 4px 5px; background-color: #fef6e3; font-family: ubuntulight;">
		<b>Maintenance:</b> Vidjil will be offline Tuesday 7, 11:00 → 13:00 CEST. Thank you for your understanding.
	    </span></div>
-->
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        </div>  
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        <!-- fin top-container-->
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        <!-- MID-CONTAINER -->
        <div id="mid-container" onmouseover="hideSelector()">
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            <!-- LEFT-CONTAINER -->
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            <div id="left-container">
            </div>
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            <!-- fin left-container -->
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            <div id="vertical-separator"></div>
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            <!-- RIGHT-CONTAINER -->
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            <div id="right-container"></div>
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            <!-- VISU-CONTAINER  -->
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            <div id="visu-container">
            </div>

        </div>
        <!-- fin mid-container -->

        <!-- BOT-CONTAINER / SEGMENTER-CONTAINER -->
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        <div id="bot-container"> </div>
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        <form id="form"></form>
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        <div id="tip-container"></div>

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    </body> 
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</html>