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As raised by @magiraud in !182 the parameters are far from being obvious

In the XML output the coordinates are 0-based: “returns the chromosomal
position of that gene in 0-based coordinates”
https://www.ncbi.nlm.nih.gov/books/NBK179288/

Are you serious guys?

Used for #3009. We just want to get the upstream or the downstream
raw sequence to be able to paste it before the allele sequence by itself.
We need to take care on the sequence orientation.

fixup ncbi.py updown

Allow to reach up to 10 rq/sec instead of 3.
See here for having one : https://ncbiinsights.ncbi.nlm.nih.gov/2017/11/02/new-api-keys-for-the-e-utilities/