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vidjil
vidjil
Commits
e178ff4e
Commit
e178ff4e
authored
Feb 16, 2015
by
Marc Duez
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core : findCDR3
parent
89c9d040
Changes
2
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2 changed files
with
72 additions
and
1 deletion
+72
-1
algo/core/segment.cpp
algo/core/segment.cpp
+70
-1
algo/core/segment.h
algo/core/segment.h
+2
-0
No files found.
algo/core/segment.cpp
View file @
e178ff4e
...
...
@@ -26,6 +26,8 @@
#include "tools.h"
#include "affectanalyser.h"
#include <sstream>
#include <string>
#include <math.h>
Segmenter
::~
Segmenter
()
{}
...
...
@@ -669,7 +671,7 @@ FineSegmenter::FineSegmenter(Sequence seq, Germline *germline, Cost segment_c)
info
=
string_of_int
(
Vend
+
FIRST_POS
)
+
" "
+
string_of_int
(
Jstart
+
FIRST_POS
)
;
findCDR3
();
finishSegmentation
();
}
...
...
@@ -781,6 +783,64 @@ void FineSegmenter::FineSegmentD(Germline *germline){
}
}
void
FineSegmenter
::
findCDR3
(){
string
str
=
getSequence
().
sequence
;
list
<
string
>
codon_start
;
codon_start
.
push_back
(
"TGT"
);
codon_start
.
push_back
(
"TGC"
);
list
<
string
>
codon_end
;
codon_end
.
push_back
(
"TTT"
);
codon_end
.
push_back
(
"TTC"
);
codon_end
.
push_back
(
"TGG"
);
list
<
int
>
p_start
;
list
<
int
>
p_end
;
size_t
loc
;
std
::
list
<
string
>::
const_iterator
it
;
for
(
it
=
codon_start
.
begin
();
it
!=
codon_start
.
end
();
++
it
)
{
//filter 1 : start codon must be in V
loc
=
0
;
while
(
loc
!=
string
::
npos
&
loc
<
Vend
){
loc
=
str
.
find
(
*
it
,
loc
+
3
);
if
(
loc
!=
string
::
npos
&
loc
<
Vend
)
{
p_start
.
push_front
(
loc
);
}
}
}
for
(
it
=
codon_end
.
begin
();
it
!=
codon_end
.
end
();
++
it
)
{
//filter 2 : end codon must be in J
loc
=
Jstart
;
while
(
loc
!=
string
::
npos
){
loc
=
str
.
find
(
*
it
,
loc
+
3
);
if
(
loc
!=
string
::
npos
)
{
p_end
.
push_back
(
loc
);
}
}
}
CDR3start
=
0
;
CDR3end
=
0
;
std
::
list
<
int
>::
const_iterator
it1
;
for
(
it1
=
p_start
.
begin
();
it1
!=
p_start
.
end
();
++
it1
)
{
std
::
list
<
int
>::
const_iterator
it2
;
for
(
it2
=
p_end
.
begin
();
it2
!=
p_end
.
end
();
++
it2
)
{
if
(
(
*
it2
-*
it1
)
%
3
==
0
){
//filter 3 : start/stop codon must be seprated by a multiple of 3
if
(
fabs
((
*
it2
-*
it1
)
-
36
)
<
fabs
((
CDR3end
-
CDR3start
)
-
36
)
){
//filter 4 : cdr3 length must be close to 12 AA
CDR3start
=
*
it1
;
CDR3end
=
*
it2
;
}
}
}
}
}
JsonList
FineSegmenter
::
toJsonList
(
Germline
*
germline
){
JsonList
result
;
...
...
@@ -802,6 +862,15 @@ JsonList FineSegmenter::toJsonList(Germline *germline){
seg
.
add
(
"3"
,
germline
->
rep_3
.
label
(
best_J
));
seg
.
add
(
"3start"
,
Jstart
);
seg
.
add
(
"3"
,
germline
->
rep_3
.
label
(
best_J
));
seg
.
add
(
"3start"
,
Jstart
);
JsonList
*
json_cdr
;
json_cdr
=
new
JsonList
();
json_cdr
->
add
(
"start"
,
CDR3start
);
json_cdr
->
add
(
"stop"
,
CDR3end
);
seg
.
add
(
"cdr3"
,
*
json_cdr
);
result
.
add
(
"seg"
,
seg
);
}
return
result
;
...
...
algo/core/segment.h
View file @
e178ff4e
...
...
@@ -46,6 +46,7 @@ protected:
string
sequence
;
int
Vend
,
Jstart
;
int
Dstart
,
Dend
;
int
CDR3start
,
CDR3end
;
bool
reversed
,
segmented
,
dSegmented
;
string
removeChevauchement
();
...
...
@@ -208,6 +209,7 @@ class FineSegmenter : public Segmenter
* @param germline: germline used
*/
void
FineSegmentD
(
Germline
*
germline
);
void
findCDR3
();
JsonList
toJsonList
(
Germline
*
germline
);
...
...
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