diff --git a/g5k-postinstall b/g5k-postinstall
index b2a003b484fe0f53362919c3cd2d4658b9cabfee..b23df9f3bb6f9e20d67af01fd1c8b060130daf14 100755
--- a/g5k-postinstall
+++ b/g5k-postinstall
@@ -769,6 +769,20 @@ if $mysite == 'nancy' and ( $mycluster == 'grcinq' or $mycluster == 'grvingt' )
   end
 end
 
+# Disable some hwloc components under Debian 11 big and std on clusters without GPU.
+# cf. Bug #13260
+unless $no_ref_api
+  envrelease = IO::read("#{DSTDIR}/etc/grid5000/release") rescue ""
+  if /debian11.*-(big|std)/.match?(envrelease) && !$myjson.key?('gpu_devices')
+    $logger.info("Disabling some hwlock components")
+    File::open("#{DSTDIR}/etc/environment", "a") do |fd|
+      fd.puts <<-EOF
+HWLOC_COMPONENTS=-opencl,-cuda,-nvml
+      EOF
+    end
+  end
+end
+
 ############################## bootloader #####################################
 
 FileUtils.mkdir_p('/var/lib/kadeploy/bootloader/')